Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591.
Identifieur interne : 000150 ( Main/Exploration ); précédent : 000149; suivant : 000151Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591.
Auteurs : RBID : pubmed:24408895English descriptors
- KwdEn :
- Animals, Brain Neoplasms (metabolism), Brain Neoplasms (radionuclide imaging), Cell Line, Tumor, Coordination Complexes (chemistry), Female, Gene Expression Regulation, Neoplastic, Glioblastoma (metabolism), Glioblastoma (radionuclide imaging), Heterocyclic Compounds, 1-Ring (metabolism), Humans, Indium Radioisotopes (metabolism), Mice, Mice, Inbred BALB C, Multimodal Imaging (methods), Neoplasm Transplantation, Positron-Emission Tomography (methods), Protein Binding, Protein Structure, Tertiary, Receptor, Platelet-Derived Growth Factor beta (metabolism), Recombinant Fusion Proteins (chemistry), Tomography, Emission-Computed, Single-Photon (methods), Tomography, X-Ray Computed (methods).
- MESH :
- chemical , chemistry : Coordination Complexes, Recombinant Fusion Proteins.
- metabolism : Brain Neoplasms, Glioblastoma, Heterocyclic Compounds, 1-Ring, Indium Radioisotopes, Receptor, Platelet-Derived Growth Factor beta.
- methods : Multimodal Imaging, Positron-Emission Tomography, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed.
- radionuclide imaging : Brain Neoplasms, Glioblastoma.
- Animals, Cell Line, Tumor, Female, Gene Expression Regulation, Neoplastic, Humans, Mice, Mice, Inbred BALB C, Neoplasm Transplantation, Protein Binding, Protein Structure, Tertiary.
Abstract
The overexpression and excessive signaling of platelet-derived growth factor receptor β (PDGFRβ) has been detected in cancers, atherosclerosis, and a variety of fibrotic diseases. Radionuclide in vivo visualization of PDGFRβ expression might help to select PDGFRβ targeting treatment for these diseases. The goal of this study was to evaluate the feasibility of in vivo radionuclide imaging of PDGFRβ expression using an Affibody molecule, a small nonimmunoglobulin affinity protein.
DOI: 10.2967/jnumed.113.121814
PubMed: 24408895
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591.</title><author><name sortKey="Tolmachev, Vladimir" uniqKey="Tolmachev V">Vladimir Tolmachev</name><affiliation wicri:level="1"><nlm:affiliation>Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Varasteh, Zohreh" uniqKey="Varasteh Z">Zohreh Varasteh</name></author><author><name sortKey="Honarvar, Hadis" uniqKey="Honarvar H">Hadis Honarvar</name></author><author><name sortKey="Hosseinimehr, Seyed Jalal" uniqKey="Hosseinimehr S">Seyed Jalal Hosseinimehr</name></author><author><name sortKey="Eriksson, Olof" uniqKey="Eriksson O">Olof Eriksson</name></author><author><name sortKey="Jonasson, Per" uniqKey="Jonasson P">Per Jonasson</name></author><author><name sortKey="Frejd, Fredrik Y" uniqKey="Frejd F">Fredrik Y Frejd</name></author><author><name sortKey="Abrahmsen, Lars" uniqKey="Abrahmsen L">Lars Abrahmsen</name></author><author><name sortKey="Orlova, Anna" uniqKey="Orlova A">Anna Orlova</name></author></titleStmt><publicationStmt><date when="2014">2014</date><idno type="RBID">pubmed:24408895</idno><idno type="pmid">24408895</idno><idno type="doi">10.2967/jnumed.113.121814</idno><idno type="wicri:Area/Main/Corpus">000216</idno><idno type="wicri:Area/Main/Curation">000216</idno><idno type="wicri:Area/Main/Exploration">000150</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain Neoplasms (metabolism)</term><term>Brain Neoplasms (radionuclide imaging)</term><term>Cell Line, Tumor</term><term>Coordination Complexes (chemistry)</term><term>Female</term><term>Gene Expression Regulation, Neoplastic</term><term>Glioblastoma (metabolism)</term><term>Glioblastoma (radionuclide imaging)</term><term>Heterocyclic Compounds, 1-Ring (metabolism)</term><term>Humans</term><term>Indium Radioisotopes (metabolism)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Multimodal Imaging (methods)</term><term>Neoplasm Transplantation</term><term>Positron-Emission Tomography (methods)</term><term>Protein Binding</term><term>Protein Structure, Tertiary</term><term>Receptor, Platelet-Derived Growth Factor beta (metabolism)</term><term>Recombinant Fusion Proteins (chemistry)</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term><term>Tomography, X-Ray Computed (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Coordination Complexes</term><term>Recombinant Fusion Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain Neoplasms</term><term>Glioblastoma</term><term>Heterocyclic Compounds, 1-Ring</term><term>Indium Radioisotopes</term><term>Receptor, Platelet-Derived Growth Factor beta</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Multimodal Imaging</term><term>Positron-Emission Tomography</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain Neoplasms</term><term>Glioblastoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Female</term><term>Gene Expression Regulation, Neoplastic</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Neoplasm Transplantation</term><term>Protein Binding</term><term>Protein Structure, Tertiary</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The overexpression and excessive signaling of platelet-derived growth factor receptor β (PDGFRβ) has been detected in cancers, atherosclerosis, and a variety of fibrotic diseases. Radionuclide in vivo visualization of PDGFRβ expression might help to select PDGFRβ targeting treatment for these diseases. The goal of this study was to evaluate the feasibility of in vivo radionuclide imaging of PDGFRβ expression using an Affibody molecule, a small nonimmunoglobulin affinity protein.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24408895</PMID><DateCreated><Year>2014</Year><Month>02</Month><Day>04</Day></DateCreated><DateCompleted><Year>2014</Year><Month>04</Month><Day>08</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1535-5667</ISSN><JournalIssue CitedMedium="Internet"><Volume>55</Volume><Issue>2</Issue><PubDate><Year>2014</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Journal of nuclear medicine : official publication, Society of Nuclear Medicine</Title><ISOAbbreviation>J. Nucl. Med.</ISOAbbreviation></Journal><ArticleTitle>Imaging of platelet-derived growth factor receptor β expression in glioblastoma xenografts using affibody molecule 111In-DOTA-Z09591.</ArticleTitle><Pagination><MedlinePgn>294-300</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2967/jnumed.113.121814</ELocationID><Abstract><AbstractText Label="UNLABELLED">The overexpression and excessive signaling of platelet-derived growth factor receptor β (PDGFRβ) has been detected in cancers, atherosclerosis, and a variety of fibrotic diseases. Radionuclide in vivo visualization of PDGFRβ expression might help to select PDGFRβ targeting treatment for these diseases. The goal of this study was to evaluate the feasibility of in vivo radionuclide imaging of PDGFRβ expression using an Affibody molecule, a small nonimmunoglobulin affinity protein.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The PDGFRβ-binding Z09591 Affibody molecule was site-specifically conjugated with a maleimido derivative of DOTA and labeled with (111)In. Targeting of the PDGFRβ-expressing U-87 MG glioblastoma cell line using (111)In-DOTA-Z09591 was evaluated in vitro and in vivo.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">DOTA-Z09591 was stably labeled with (111)In with preserved specific binding to PDGFRβ-expressing cells in vitro. The dissociation constant for (111)In-DOTA-Z09591 binding to U-87 MG cells was determined to be 92 ± 10 pM. In mice bearing U-87 MG xenografts, the tumor uptake of (111)In-DOTA-Z09591 was 7.2 ± 2.4 percentage injected dose per gram and the tumor-to-blood ratio was 28 ± 14 at 2 h after injection. In vivo receptor saturation experiments demonstrated that targeting of U-87 MG xenografts in mice was PDGFRβ-specific. U-87 MG xenografts were clearly visualized using small-animal SPECT/CT at 3 h after injection.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This study demonstrates the feasibility of in vivo visualization of PDGFRβ-expressing xenografts using an Affibody molecule. Further development of radiolabeled Affibody molecules might provide a useful clinical imaging tool for PDGFRβ expression during various pathologic conditions.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tolmachev</LastName><ForeName>Vladimir</ForeName><Initials>V</Initials><Affiliation>Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.</Affiliation></Author><Author ValidYN="Y"><LastName>Varasteh</LastName><ForeName>Zohreh</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Honarvar</LastName><ForeName>Hadis</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Hosseinimehr</LastName><ForeName>Seyed Jalal</ForeName><Initials>SJ</Initials></Author><Author ValidYN="Y"><LastName>Eriksson</LastName><ForeName>Olof</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Jonasson</LastName><ForeName>Per</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Frejd</LastName><ForeName>Fredrik Y</ForeName><Initials>FY</Initials></Author><Author ValidYN="Y"><LastName>Abrahmsen</LastName><ForeName>Lars</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Orlova</LastName><ForeName>Anna</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>01</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Nucl Med</MedlineTA><NlmUniqueID>0217410</NlmUniqueID><ISSNLinking>0161-5505</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>111In-DOTA-Z09591</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Coordination Complexes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Heterocyclic Compounds, 1-Ring</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Recombinant Fusion Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>60239-18-1</RegistryNumber><NameOfSubstance>1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber><NameOfSubstance>Receptor, Platelet-Derived Growth Factor beta</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Brain Neoplasms</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Coordination Complexes</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Gene Expression Regulation, Neoplastic</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Glioblastoma</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Heterocyclic Compounds, 1-Ring</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Multimodal Imaging</DescriptorName><QualifierName MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Neoplasm Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Positron-Emission Tomography</DescriptorName><QualifierName MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Protein Binding</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Protein Structure, Tertiary</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Receptor, Platelet-Derived Growth Factor beta</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Recombinant Fusion Proteins</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tomography, Emission-Computed, Single-Photon</DescriptorName><QualifierName MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName><QualifierName MajorTopicYN="N">methods</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">111In</Keyword><Keyword MajorTopicYN="N">Affibody molecule</Keyword><Keyword MajorTopicYN="N">PDGFRβ</Keyword><Keyword MajorTopicYN="N">U-87 MG xenograft</Keyword><Keyword MajorTopicYN="N">molecular imaging</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>1</Month><Day>9</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24408895</ArticleId><ArticleId IdType="pii">jnumed.113.121814</ArticleId><ArticleId IdType="doi">10.2967/jnumed.113.121814</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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